Ferumoxytol: A Multifunctional Nanomedicine for Iron Deficiency synthesised

Introduction Ferumoxytol is a colloidal superparamagnetic iron-carbohydrate complex that has been widely used as an intravenous iron replacement therapy for patients suffering from iron deficiency anaemia (IDA) and those with chronic kidney disease (CKD).[1] Traditional iron supplements, including oral formulations, often present challenges such as poor bioavailability, gastrointestinal intolerance, and a prolonged treatment timeline. Intravenous iron therapies, including Ferumoxytol, provide…

A comprehensive review of enhanced bioavailability, nutraceutical efficacy, and superior manufacturing quality of Liposomal Curcumin by WBCIL

1. Introduction Curcumin, the principal bioactive component of Curcuma longa (turmeric), has garnered significant scientific interest due to its potent anti-inflammatory, antioxidant, and anticancer properties.[1] Despite its promising therapeutic potential, clinical application of curcumin has been severely limited by its poor water solubility, instability in physiological conditions, and rapid systemic elimination, resulting in extremely low oral bioavailability.[1] Conventional curcumin formulations…

First Evidence of Phyto-Melatonin as a Protective Bio-Molecule in Capra hircus

Introduction Melatonin is an evolutionarily conserved molecule found across diverse life forms [1]. Initially known for its presence in animals, it was later identified in plants during the nineteenth century, leading to the concept of phyto-melatonin—the plant-derived form of melatonin [2]. Recent research indicates that phyto-melatonin is not limited to higher plants; it is also present in various macro- and…

Albucasis Role in the Development of Perineal Cystolithotomy: A Historical systemic Review

Introduction Descriptions of Perineal cystolithotomy can be found in ancient Indian, Chinese, Babylonian, and Greek medical texts. An Egyptian excavation revealed the oldest bladder stone, which dates to around 4800 BCE, in the grave of a 16-year-old boy. In 1901, the English archaeologist Edwin Smith reported the discovery of a bladder stone in a mummy from El Amrah, Egypt, estimated…

From Galens De Sanitate Tuenda to Holistic Health: A Historical Study of the Six Non-Natural Factors

1. Introduction By the second century CE, the Roman Empire had become a vast arena of cultural exchange and intellectual synthesis. Greek philosophical medicine—rooted in classical medical corpus—had merged with Roman empiricism and Stoic ethics to produce a new medical humanism. Within this context, a prominent physician-philosopher of antiquity emerged as the most influential figure of the era, shaping medical…

Cost Effectiveness and Accessibility Considerations of Phytochemical Containing Pharmaceuticals

The integration of phytochemicals into pharmaceutical development represents a paradigm shift toward more sustainable and economically viable therapeutic solutions. Phytochemicals, defined as bioactive compounds found in plants, have emerged as key players in promoting health and preventing diseases, with their natural occurrence in fruits, vegetables, grains, and seed oils making them inherently safer for consumption [1, 2]. The global phytochemicals…

Reptile Gel as a Non-Invasive Topical Therapy for Erectile Dysfunction: Findings from the First Clinical Trial and Future Directions of WBCIL

1. Introduction Reptile Gel is an innovative topical solution for erectile dysfunction (ED), designed to offer a fast-acting, non-invasive, and drug-free alternative to traditional treatments.[1] Unlike oral medications, which require systemic absorption and may cause side effects, Reptile Gel works through a physical evaporative cooling mechanism that stimulates nerve endings in the glans penis, triggering vasodilation and increased blood flow.[2]…

Measuring the Risk: Hypoglycemia in Newborns of Diabetic Mothers-Cross Sectional Study

Introduction: Neonatal hypoglycemia remains one of the most frequently encountered and clinically significant metabolic issues in newborns, particularly in those with identifiable risk factors. It results from the neonate’s immature ability to regulate blood glucose after separation from the maternal circulation. Since glucose is the brain’s primary energy source and neonatal brain metabolism is exceptionally high, inadequate glucose levels can…

Herbal Remedies for Diabetes: Insights from Indian Medicinal Plants

IntroductionDiabetes mellitus (DM), commonly referred to as diabetes, originates from the Greek word diabino, meaning “to pass through,” referring to the excessive excretion of glucose in urine. It is a chronic metabolic and, in some cases, autoimmune disorder characterized by persistently elevated blood glucose levels due to either insufficient insulin secretion, impaired insulin action, or both [1]. When blood sugar…