Therapeutic Potential of Herbal and Natural Product-Based Pharmaceuticals in Modern Healthcare Systems

1. Introduction Natural products have served as the foundation of medicinal therapy since the earliest civilizations. Ancient healthcare systems such as Ayurveda, Traditional Chinese Medicine, Unani, and various indigenous healing practices have relied extensively on medicinal plants and natural substances for disease prevention and treatment. Even in the era of modern pharmaceutical sciences, natural products continue to contribute significantly to…

Apigenin ‘s Dual Action on Pain and Inflammation: Mechanistic Insights Through NO, COX, and Oxidative Stress Pathways

Flavonoids constitute a broad class of naturally occurring polyphenolic compounds that are widely distributed in fruits, vegetables, herbs, and medicinal plants. These bioactive compounds are well recognized for their diverse pharmacological properties, including antioxidant, anti-inflammatory, analgesic, antimicrobial, and neuroprotective activities [1]. Due to their significant therapeutic potential and relatively low toxicity, flavonoids have attracted considerable scientific attention as promising candidates…

Cosmeceutical Role of Medicinal Plants and Herbs: Therapeutic and Cosmetic Perspectives

Introduction The intersection of cosmetics and pharmaceuticals has given rise to the rapidly evolving field of cosmeceuticals, where bioactive ingredients derived from medicinal plants and herbs serve both therapeutic and aesthetic purposes. Cosmeceuticals represent a unique category of topical products that transcend traditional cosmetics by incorporating biologically active compounds capable of influencing skin structure and function at the cellular level…

Import substitution within the framework of global trade in Medicinal Plants: A potential consideration for homologated phytomedicines in Cameroon

INTRODUCTION Import substitution is a well-intended economic concept geared towards meeting the needs of a wider sector of a nation’s general demand for goods (production and imports), by her self-domestic production [1, 2]. Import substitution within the framework of the medicinal plants sector has generated more interest in Cameroon as the country reflects on her vision 2035 economic plan. Efforts…

Nigella sativa in Traditional and Modern Medicine: Pharmacological Evidence and Future Prospects

Introduction Over the past two decades, there has been a growing global interest in alternative and traditional systems of medicine, as many individuals increasingly seek natural therapeutic options alongside or in place of conventional allopathic treatments, particularly for chronic diseases [1-5]. Traditional medical systems such as Unani, Ayurveda, and Siddha continue to play a significant role in healthcare due to…

Ferumoxytol: A Multifunctional Nanomedicine for Iron Deficiency synthesised

Introduction Ferumoxytol is a colloidal superparamagnetic iron-carbohydrate complex that has been widely used as an intravenous iron replacement therapy for patients suffering from iron deficiency anaemia (IDA) and those with chronic kidney disease (CKD).[1] Traditional iron supplements, including oral formulations, often present challenges such as poor bioavailability, gastrointestinal intolerance, and a prolonged treatment timeline. Intravenous iron therapies, including Ferumoxytol, provide…

A comprehensive review of enhanced bioavailability, nutraceutical efficacy, and superior manufacturing quality of Liposomal Curcumin by WBCIL

1. Introduction Curcumin, the principal bioactive component of Curcuma longa (turmeric), has garnered significant scientific interest due to its potent anti-inflammatory, antioxidant, and anticancer properties.[1] Despite its promising therapeutic potential, clinical application of curcumin has been severely limited by its poor water solubility, instability in physiological conditions, and rapid systemic elimination, resulting in extremely low oral bioavailability.[1] Conventional curcumin formulations…

First Evidence of Phyto-Melatonin as a Protective Bio-Molecule in Capra hircus

Introduction Melatonin is an evolutionarily conserved molecule found across diverse life forms [1]. Initially known for its presence in animals, it was later identified in plants during the nineteenth century, leading to the concept of phyto-melatonin—the plant-derived form of melatonin [2]. Recent research indicates that phyto-melatonin is not limited to higher plants; it is also present in various macro- and…

Albucasis Role in the Development of Perineal Cystolithotomy: A Historical systemic Review

Introduction Descriptions of Perineal cystolithotomy can be found in ancient Indian, Chinese, Babylonian, and Greek medical texts. An Egyptian excavation revealed the oldest bladder stone, which dates to around 4800 BCE, in the grave of a 16-year-old boy. In 1901, the English archaeologist Edwin Smith reported the discovery of a bladder stone in a mummy from El Amrah, Egypt, estimated…